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Panagiotis Papageorgis
Dean, Professor, Biological Sciences
22713158
The School of Sciences
0
Academic Qualifications
Qualification Year Awarding Institution Department Thesis title
PhD 2009 Boston University School of Medicine Cell and Molecular Biology/ Genetics and Genomics The role of Smad signaling in cancer progression
BSc 2003 National and Kapodistrian University of Athens Biology Purification and biochemical characterization of an endogenous inhibitor of L-Dopa decarboxylase
Employment History
Period of employment Employer Location Position
From To
2014 date European University Cyprus Nicosia, Cyprus Associate Professor
2010 2014 University of Cyprus Nicosia, Cyprus Post-doctoral fellow
2009 2010 Boston University School of Medicine Boston, USA Post-doctoral fellow
Publications
Year Title Other authors Journal and Publisher / Conference Vol. Pages
2021 Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance Demetriadou, A. Raoukka, E. Charidemou, C. Mylonas, C. Michael, S. Parekh, C. Koufaris, P. Skourides, P. Tessarz and A. Kirmizis Oncogene Doi: 10.1038/s41388-021-02113-9
2021 Apoptosis deregulation and the development of multi-drug resistance C.M. Neophytou, I. Trougakos and N. Erin Cancers 13 https://doi.org/10.3390/cancers13174363
2021

The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities

C.M. Neophytou, M. Panagi, T. Stylianopoulos Cancers 13 https://doi.org/10.3390/cancers13092053
2020 Normalizing the microenvironment overcomes vessel compression and resistance to nano-immunotherapy in breast cancer lung metastasis F. Mpekris, M. Panagi, C. Voutouri, J. Martin, R. Samuel, S. Takahashi, N. Gotohda, T. Suzuki, P. Demetriou, C. Pierides, L. Koumas, P. Costeas, M. Kojima, G. Ishii, A. Constantinidou, K. Kataoka, H. Cabral, T. Stylianopoulos Advanced Science 8  https://doi.org/10.1002/advs.202001917
2019 Activin A Signaling Regulates IL13Rα2 Expression to Promote Breast Cancer Metastasis Kalli M, Mpekris F, Wong CK, Panagi M, Ozturk S, Thiagalingam S, Stylianopoulos T. Frontiers in Oncology 9 doi: 10.3389/fonc.2019.00032
2018 Molecular mechanisms and emerging therapeutic targets for triple-negative breast cancer metastasis C.N. Neophytou, P. Boutsikos Frontiers in Oncology 8 https://doi.org/10.3389/fonc.2018.00031
2017 Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner C. Polydorou, F. Mpekris, C. Voutouri, E. Agathokleous, C. Kapnissi-Christodoulou, T. Stylianopoulos Scientific Reports 7 doi: 10.1038/srep46140
2015 Targeting IL13RA2 activates STAT6-p63 pathway to suppress breast cancer lung metastasis. Ozturk S., Lambert A.W., Tzatsos A., Neophytou C.M., Wong C.K., Thiagalingam S. Constantinou AI. Breast Cancer Research 17 doi: 10.1186/s13058-015-0607-y
2011 Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cheng K.H., Ozturk S., Gong Y., Lambert AW., Abdolmaleky H.M., Zhou JR., Thiagalingam S. Cancer Research 71 998-1008
2010 Smad signaling is required to maintain epigenetic gene silencing during breast cancer progression Lambert A.W., Ozturk S., Gao F., Pan H., Manne U., Alekseyev Y., Thiagalingam A., Abdolmaleky H., Lenburg M.,Thiagalingam S. Cancer Research 70 968-978
Exhibitions
Date Topic International / Local Location* Role in Exhibition
2021 Unveiling the transcriptional landscape that regulates colonization of dormant metastatic breast cancer cells to the lungs International Nicosia, Cyprus Talk
2020 Remodelling the tumor microenvironment to improve the efficacy of immunotherapy International Athens, Greece Invited talk
2019 Remodelling the tumor microenvironment to improve the efficacy of cancer therapy. International Nicosia, Cyprus Invited talk
2018 Remodelling the tumor microenvironment to improve efficacy of chemo- and nanotherapeutics in solid tumors International Lausanne, Switzerland Poster presentation
2017 IL13Rα2: a target for controlling breast cancer metastasis to the lungs. Local Limassol, Cyprus Invited talk
2017 Designing strategies to target IL13Ra2-mediated breast cancer metastasis. International Athens, Greece Invited talk
2017 Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size independent manner. International Basel, Switzerland Poster presentation
2016 Deciphering the molecular complexity of cancer metastasis. International Athens, Greece Invited talk
2016 Molecular mechanisms of cancer metastasis Local Larnaca, Cyprus Invited talk
2015 Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer metastasis. International Athens, Greece Invited talk
Research Projects
Date Title Funded by Project Role*
03/2021 - 02/2023 Targeting the desmoplastic tumor microenvironment to improve the efficacy of pancreatic cancer immunotherapy Research and Innovation Foundation (EXCELLENCE 0421/0179) Allocated funding: 174,533.25 € Project coordinator
03/2021 - 02/2023 Investigating the mechanistic and therapeutic link between glucose and Histone acetyltransferase 1 (HAT1) activity in the aggressiveness of Glioblastoma multiforme (GBM) Research and Innovation Foundation (EXCELLENCE 0421/0342) Allocated funding: 74,749.60 € Project Partner
03/2021 - 02/2023 Deciphering the molecular and biological function of histone H2A.X N-terminal acetylation Research and Innovation Foundation (EXCELLENCE 0421/0152) Allocated funding: 74.449,00 € Project Partner
01/2019 - 12/2021 Unveiling novel molecular mechanisms that regulate colonization of dormant metastatic breast cancer cells. Research and Innovation Foundation (POST-DOC 0916/0044) Allocated funding: 159.992 € Project Partner
09/2019 - 08/2021 Optimizing immunotherapy in triple-negative breast cancer by normalizing the tumor microenvironment Research and Innovation Foundation (POST-DOC 0718/0084) Allocated funding: 15.600 € Project Partner
09/2019 - 08/2021 Function of the histone N-terminal acetyltransferase Naa40 in liver-metabolic reprogramming and oncogenesis Research and Innovation Foundation (EXCELLENCE  0918/0081) Allocated funding: 15.000 € Project Partner
01/2019 - 12/2022 Center for Preclinical evaluation and optimization of cancer nanomedicine Research and Innovation Foundation (INFRASTRUCTURES  1216/0052) Allocated funding: 39,552 € Project Partner
01/2019 - 12/2021 Functional and therapeutic implications of histone N-terminal acetyltransferase Naa40 in colorectal oncogenesis Research and Innovation Foundation (EXCELLENCE  1216/0036) Allocated funding: 34,488 € Project Partner
06/2016 - 05/2018 Elucidation of the signaling mechanisms that promote IL13Rα2-mediated breast cancer metastasis Research and Innovation Foundation (KOULTOURA 0415/03) Χρηματοδότηση: 35.000 € Project coordinator
09/2010 - 12/2013 Identification and functional characterization of novel genes involved in breast cancer metastasis Research and Innovation Foundation (DIDAKTOR 0609/24) Allocated funding: 150.000 € Project coordinator
Academic Consulting Services/Councils/Boards/Editorial Committees
Period Organization Title of Position or Service Key Activities
09/2018 – to date European University Cyprus Dean, School of Sciences Academic and Administrative leader of the School of Sciences, responsible for the academic operations, general welfare and the development of the School.
2021-2027 Program Committee - Horizon Europe National Representative of the “Health” Configuration of Horizon Europe Program Committee Promotion of national positions in the formulation of Horizon Europe Call programs in the "Health" Configuration.
2021-2024 National Committee for the Protection of Animals for Scientific Purposes Member of the National Committee for the Protection of Animals for Scientific Purposes Evaluation and licensing of work permit applications and personal permits for the use of animals for scientific purposes
2021 National Science Center, Poland Grant proposal reviewer Review of grant proposals
2019-to date European University Cyprus Coordinator of the MSc Cancer Biology Program Responsible all academic operations and matters pertaining the MSc Cancer Biology program.
Awards/International Recognition
Date Title Awarded by:
2015 Young Researcher Award Research Promotion Foundation Cyprus
2007 First prize for the Henry I. Russek Student Achievement Award Boston University School of Medicine
2006 Second prize for the Henry I. Russek Student Achievement Award Boston University School of Medicine
2006 Honourable mention for the Evans Research Day Boston University School of Medicine
2005 First prize for the “Outstanding poster award competition” Boston University School of Medicine, Department of Genetics and Genomics
Other Achievements
Date Title Key Activities:
2006 – to date 42 articles in international peer-reviewed journals and 4 book chapters Author/Researcher
2006 – to date Citations: 2672; h-index: 22; i10-index: 32 (source Google Scholar, as of 23/11/21) https://scholar.google.com/citations?user=10jCj7kAAAAJ&hl=en Author/Researcher
2010 - to date Reviewer Manuscript reviews for several peer-reviewed journals
2018 Scientific committee member Member of the Scientific committee for the 7th International Conference of the Cyprus Society of Human Genetics
2018 Scientific committee member Member of the Scientific committee for the 6th Multithreaded Biomedical Congress
2017 Founding member of Pancyprian Association for Cystic Fibrosis Founding member
2016 Ad hoc evaluations Member of the several PhD Examination Committee at the University of Cyprus, the Cyprus Institute of Neurology and Genetics and National and Kapodistrian University
July 2016-July 2017 EUC Faculty Development Completion of the EUC Faculty Development Program
2016 Invited lecturer Invited lecture “Deciphering the molecular complexity of cancer metastasis”. 12th Educational Biology Conference OELMEK, Nicosia, Cyprus
2012 Invited lecturer Invited lecture “Integrating transcriptomic and genetic approaches to identify novel mediators of breast cancer metastasis”. Progress in combination therapy of cancer using novel immunomodulators, “Inspire” Conference, Athens, Greece