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Anastasis Stephanou

Anastasis Stephanou

Professor, Molecular & Cellular Biology


School of Medicine

Department of Medicine

Academic Qualifications

Qualification Year Awarding Institution Department Thesis title
PhD        (Molecular Endocrinology) 1989 -1992 Charing Cross & Westminster Med Sch (London) Medicine Neuro-Immuno Communication
MSc       (Molecular Biology) 1988 -1990 Birkbeck College (London) Biology Neuropeptide Expression in Lymphocytes
BSc  2:1 (Immunology/Biochemistry) 1981 -1985 North East London Polytech

Employment History

Period of employment Employer Location Position
From To
2013 present School of Medicine, European University Cyprus Nicosia Professor (Cell Biology & Genetic)
2005 2013 Medical Molecular Biology Unit,  Institute of Child Health, UCL London Reader/Associate professor (Molecular & Cellular Biology)
2002 2005 Institute of Child Health, University College London (UCL) London Lecturer in the Medical Molecular Biology Unit


Year Title Other authors Journal and Publisher / Conference
2018 Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways .Yiallouris A, Patrikios I, Johnson EO, Sereti E, Dimas K, De Ford C, Fedosova NU, Graier WF, Sokratous K, Kyriakou K, Stephanou A. . (2018) Cell Death Dis. 9(7):764. doi: 10.1038
2017  Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK. Bourke LT, McDonnell T, McCormick J, Pericleous C, Ripoll VM, Giles I, Rahman A, Stephanou A, Ioannou Y. Cell Death Dis.;8(1):e2549. doi: 10.1038.
2015 Hydroxychloroquine Protects against Cardiac Ischaemia/Reperfusion Injury In Vivo via Enhancement of ERK1/2 Phosphorylation. Bourke L, McCormick J, Taylor V, Pericleous C, Blanchet B, Costedoat-Chalumeau N, Stuckey D, Lythgoe MF, Stephanou A, Ioannou Y. PLoS One 10(12):e0143771. doi: 10.1371.
2015 MultiElec: A MATLAB Based Application for MEA Data Analysis. Georgiadis V, Stephanou A, Townsend PA, Jackson TR PLoS One.;10(6):e0129389. doi: 10.1371.
2014 Cardiac tissue engineering: renewing the arsenal for the battle against heart disease. Georgiadis V, Knight RA, Jayasinghe SN, Stephanou A. Integr Biol (Camb). 2):111-26. doi: 10.1039
2004 Epigallocatechin-3-gallate Inhibits STAT1 Activation and Protects the myocardium from Ischemia/Reperfusion–Induced Apoptosis. Townsend, P. Davidson, S. Scarabelli, Knight, R.A., Latchman, D.S., Stephanou, A. FASEB J. 18:1621-1623.
2004 STAT1 interacts with p53 to enhance DNA damage –induced apoptosis. Townsend, P. Davidson, S. Scarabelli, Knight, R.A., Latchman, D.S., Stephanou, A. J. Biol Chem. 297:5811-5819.
2002 Different signalling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischaemia/reperfusion injury. Scarabelli TM, Stephanou A, Pasini E, Comini L, Raddino R, Knight RA, Latchman DS. Circ Res. 90:745-748.
2001 Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury. Stephanou, A., Brar, B. Scarabelli, T., Knight, R.A. & Latchman, D.S. Cell Death & Differentiation 8, 434-435.
2000 Ischaemia-induced STAT1 expression and activation plays a critical role in cardiac myocyte apoptosis. Stephanou, A., Brar, B., Knight, R.A., Marber, M.S. Yellon, D. & Latchman, D.S. (2000). J. Biol Chem  275. 10002-10008.


Research Projects

Date Title Funded by Project Role*
Jan 2012-Jan 2015 Bio-electrospraying Cardiac Cells: a novel direct tissue engineering and regenerative medicinal approach for bio-repairing the heart.. £265,101. British Heart Foundation  New Horizons grant. A.S Principle Investigator
Feb 2009- Jan 2012 Role of p53 and STAT1 in regulating the autophagic pathway in the ischaemic myocardium. British Heart Foundation Project Post-doc grant. PG/08/091/26002. Principle Investigator
May 2008-April 2011 Bio-electrospraying: a novel approach in cardiac tissue engineering £126, 082 British Heart Foundation Project Post-doc grant. PG/07/111/24002. A.S Principle Investigator
July 2006-June 2008 The role of autophagy in the ischaemic myocardium.  £106,904. British Heart Foundation  Project post-doc grant PG/05/118/19834. Principal supervisor
March 2005- February 2008 Role of STAT1 interaction with p53 family members during ischaemia/reperfusion injury in the myocardium. £139,166. British Heart Foundation  Project Post-doc grant PG/04/077/17362 Principal Investigator

Academic Consulting Services/Councils/Boards/Editorial Committees

Awards/International Recognition

Other Achievements