Antonia Sophocleous
Assistant Professor, Biochemistry
22559614
School of Sciences
Department of Life Sciences
Academic Qualifications
| Qualification | Year | Awarding Institution | Department | Thesis title (Optional Entry) |
| Doctor of Philosophy (PhD) in Molecular Medicine | 2005-2009 | The University of Edinburgh | Department of Rheumatic Diseases, UK | The Role of Cannabinoid Receptor 2 (CB2) in Bone Metabolism |
| Bachelor of Science (BSc Hons) in Molecular Biology and Biochemistry | 2001-2004 | Durham University | Department of Biological Sciences, UK |
Employment History
| Period of employment | Employer | Location | Position | |
| From | To | |||
| 2016 | Present | European University Cyprus | School of Sciences | Lecturer in Biochemistry |
| 2016 | Present | The University of Edinburgh, CGEM, IGMM | Department of Rheumatic Disease | Honorary Fellow |
| 2009 | 2016 | The University of Edinburgh, CGEM, IGMM | Department of Rheumatic Diseases | Post Doctoral Research Fellow |
Publications
| Year | Title | Other authors | Journal and Publisher / Conference | Vol. | Pages |
| 2019 | Raman spectroscopy as a predictive tool for monitoring osteoporosis therapy in a rat model of postmenopausal osteoporosis | Beattie J.R., Sophocleous A., Caraher M.C., O'Driscoll O., Cummins N.M., Bell S.E.J., Towler M., Rahimnejad Yazdi A., Ralston S.H., Idris A.I. | J Mater Sci Mater Med. | 30(2): 25 | NA |
| 2018 | Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a rodent model of oestrogen deficiency. | Caraher M.C., Sophocleous A., Beattie J.R., O'Driscoll O., Cummins N.M., Brennan O., O'Brien F.J., Ralston S.H., Bell S.E.J., Towler M., Idris A.I. | Biochim. Biophys. Acta | 1864 (2) | 398-406 |
| 2017 | Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition. | Sophocleous A., Marino S., Kabir D., Ralston S.H. and Idris A.I. | Ageing Cel | 16 (5) | 1051-1061. |
| 2017 | Heavy cannabis use is associated with low bone mineral density and an increased risk of fractures. | Sophocleous A., Robertson R., Ferreira N.B., McKenzie J., Fraser W.D. and Ralston S.H. | Am. J. Med. | 130 (2) | 214-221 |
| 2015 | Bone cell-autonomous contribution of type 2 cannabinoid receptor to breast cancer induced osteolysis. | Sophocleous A., Marino S., Logan J.G., Mollat P., Ralston S.H. and Idris A.I. | Journal of Biological Chemistry | 290 (36) | 22049-22060 |
| 2015 | The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice. | Sophocleous A., Börjesson A.E., Salter D.M. and Ralston S.H. | Osteoarthritis and Cartilage | 23 (9) | 1586-1594. |
| 2014 | Rodent models of osteoporosis. | Sophocleous A. and Idris A.I. | BoneKEy Reports | 3 | 614 |
| 2014 | Modulation of strain-specific differences in gene expression by cannabinoid type 2 receptor deficiency. | Sophocleous A., Sims A.H., Idris A.I. and Ralston S.H. | Calcified Tissue International | 94 (4) | 423-432. |
| 2011 | The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation. | Sophocleous A., Landao-Bassonga E., van’t Hof R.J., Idris A.I. and Ralston S.H. | Endocrinology | 152 (6) | 2141-2149 |
| 2009 | Cannabinoid receptor type 1 protects against age-related bone loss by regulating osteoblast and adipocyte differentiation in marrow stromal cells. | Idris A.I., Sophocleous A., Landao-Bassonga E., Canals M., Milligan G.I., Baker D., van’t Hof R.J. and Ralston S.H. | Cell metabolism | 10 | 139-147 |
Exhibitions
Research Projects
| Date | Title | Funded by | Project Role* |
| July 2016 - Present | The role of microbiome in osteoarthritis development | Genomic and Experimental Medicine (CGEM), University of Edinburgh | Scientific coordinator |
| 02/01/2008 - 01/07/2015 | Regulation of bone metabolism by cannabinoid receptors: mechanisms of action and implications for the treatment of bone disease | Arthritis Research UK | Researcher |
Academic Consulting Services/Councils/Boards/Editorial Committees
| Period | Organization | Title of Position or Service | Key Activities |
| January 2019 – Present | HubLE (The IFMRS knowledge platform); IFMRS = International Federation of Musculoskeletal Research Societies | Co-chair | Member of the editorial board |
| 2011- Present | Calcified Tissue International (Springer), Frontiers in Endocrinology (Open Access), Frontiers in Pharmacology (Open Access), PLOS ONE (Open Access), British Journal of Pharmacology (Wiley Online Library), Molecular and Cellular Biochemistry (Springer), BMC Musculoskeletal Disorders (Open Access) | Reviewer of Scientific Journals | Peer reviewing articles |
Awards/International Recognition
| Date | Title | Awarded by: |
| 2013 | 40th European Symposium on Calcified Tissues | Lisbon, Portugal |
| 2012 | 39th European Symposium on Calcified Tissues | Stockholm, Sweden |
| 2011 | 3rd joint meeting ECTS/IBMS | Athens, Greece |
| 2010 | 10th International Meeting on Cancer Induced Bone Disease | Sheffield, UK |
| 2010 | 37th European Symposium on Calcified Tissues | Glasgow, UK |
| 2009 | 36th European Symposium on Calcified Tissues | Vienna, Austria |
| 2008 | 35th European Symposium on Calcified Tissues | Barcelona, Spain |
| 2008 | International Bone and Mineral Society | Davos, Switzerland |
| 2007 | 34th European Symposium on Calcified Tissues | Copenhagen, Denmark |
Other Achievements
| Date | Title | Key Activities: |
| 2005-2009 | Principal’s Scholarship, University of Edinburgh (PhD Scholarship) | PhD |