Apostolos Zaravinos
Associate Professor, Biological Sciences
A.Zaravinos@euc.ac.cy
22559577
The School of Sciences
Department of Life Sciences
Academic Qualifications
| Qualification | Year | Awarding Institution | Department | Thesis title (Optional Entry) |
| Specialization in Genomic Data Science | 2017-2018 | Johns Hopkins University, Baltimore, Maryland, USA | McKusick-Nathans Institute of Genetic Medicine | Differential expression between fetal and aged brains |
| Specialization in Systems Biology | 2014-2015 | Systems Biology Center, New York, USA | Icahn School of Medicine, Mount Sinai | Identification of deregulated genes after single gene perturbation in mammalian cell lines or tissues |
| PhD in Medicine (par excellence) | 2005-2008 | University of Crete, Greece | School of Medicine | Mutations and differential expression of the oncogenes RAS and BRAF and detection of viral DNA in human nasal polyposis |
| BSc in Biology | 2000-2005 | University of Crete, Greece | Department of Biology | The role of Fras1/Frem proteins in basement membrane function |
Employment History
| Period of employment | Employer | Location | Position | |
| From | To | |||
| June 2019 | today | European University Cyprus | Department of Life Sciences, School of Sciences, Nicosia, Cyprus | Associate Professor |
| October 2015 | May 2019 | European University Cyprus | Department of Life Sciences, School of Sciences, Nicosia, Cyprus | Assistant Professor |
| February 2014 | February 2016 | Karolinska Institutet | Department of Laboratory Medicine, Laboratory of Immunogenetics, Stockholm, Sweden | Senior Post-Doctoral Research Fellow |
Publications
| Year | Title | Other authors | Journal and Publisher / Conference | Vol. | Pages |
| 2021 | Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis | Roufas C, Georgakopoulos-Soares I, Zaravinos A | NAR Cancer | 3(1) | zcab005 |
| 2020 | Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer | Mastrogamvraki N, Zaravinos A | NPJ Syst Biol Appl | 6(1) | 23 |
| 2020 | High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer | Kitsou M, Ayiomamitis GD, Zaravinos A | Int J Oncol | 57(1) | 237-248 |
| 2020 | Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers | Panayiotou T, Michael S, Zaravinos A, et al. | PLoS pathogens | 16(4) | e1008468 |
| 2020 | EMT factors and metabolic pathways in cancer | Georgakopoulos-Soares I, Chartoumpekis DV, Kyriazopoulou V, Zaravinos A | Front Oncol | 10 | 499 |
| 2020 | Current perspectives in cancer immunotherapy | Christofi T, Baritaki S, Falzone L, et al | Cancers | 11(10) | 1472 |
| 2019 | Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer | Zaravinos A, Roufas C, Nagara M, et al. | J Exp Clin Cancer Res | 38(1) | 364 |
| 2016 | Extraction and Analysis of Mammalian Gene Expression Signatures from GEO by the Crowd. | Wang Z, Monteiro CD, Jagodnik KM, et al. | Nat Commun | 7 | 12846 |
| 2015 | Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells. | Björkman A, Qvist P, Du L, et al. | Proc Natl Acad Sci U S A | 112(7) | 2157-62. |
| 2014 | Exome sequencing reveals novel mutation targets in diffuse large B cell lymphomas derived from Chinese patients. | de Miranda NFCC, Georgiou K, Chen L, et al. | Blood | 124(16) | 2544-53 |
Exhibitions
| Date | Topic | International / Local | Location* | Role in Exhibition |
| 4-5 December 2020 | Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis | 8th International Cyprus Society of Human Genetics (CSHG) Virtual conference | Nicosia, Cyprus | Invited oral presentation |
| 9-14 November 2020 | Distinct genomic features across cytolytic subgroups in skin melanoma | Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting during SITC 2020 | Virtual | Poster presentation |
| 8-11 October 2020 | Systems Approaches in the Common Metabolomics in Acute Lymphoblastic Leukemia and Rhabdomyosarcoma Cells: A Computational Approach | GeNeDis 2020: Genetics, Geriatrics and Neurodegenerative diseases 2020 | FORTH Foundation The Foundation for Research and Technology - Hellas (FORTH), Heraklion, Crete, Greece | Oral presentation |
| 4-6 November 2019 | Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer | EMBL Cancer Genomics 2019 | Heidelberg, Germany | Oral presentation |
| 10-12 October 2019 | Correlation of the expression of immune checkpoint molecules with the tumor-infiltrating lymphocyte load, and survival in colorectal cancer patients | 24th World Congress on Advances in Oncology & 24th International Symposium on Molecular Medicine | Mystras, Sparta, Greece | Oral presentation |
| 7-12 July 2018 | Prognostic impact of immune cytolytic activity and its association with checkpoint molecules and TIL/TAN load in human malignancies | The FEBS Congress 2018 - Prague, Czech Republic (International) | Prague, Czech Republic | Poster presentation |
| 17-20 March 2018 | Nrf2 Prevents Notch-induced Insulin Resistance And Tumorigenesis In Mice | ENDO2018 (International) | Chicago, Illinois, USA | Oral presentation |
| 5-8 November 2017 | Immune cytolytic activity in colorectal cancer | Cancer Genomics (International) | EMBL Heidelberg, Germany | Poster presentation |
| February 8-13, 2015 | A novel IGH-PDL1 translocation is associated with PDL1 overexpression in a diffuse large B cell lymphoma | Tumor Immunology: Multidisciplinary Science Driving Combination Therapy (International) | Fairmont Banff Springs, Banff, Alberta, Canada | Poster presentation |
| 17-20 June, 2015 | Exome and whole genome sequencing reveals novel genetic alterations in diffuse large B-cell lymphomas derived from Chinese patients | 13th International Conference on Malignant Lymphoma (International) | Lugano, Switzerland | Oral presentation |
Research Projects
| Date | Title | Funded by | Project Role* |
| June 2018 | Functional and therapeutic implications of histone N-terminal acetyltransferase Naa40 in colorectal oncogenesis | Research Promotion Foundation Cyprus (EXCELLENCE/1216/0036) Funding: 250.000,00 € | Researcher |
| June 2018 | Genetic modifiers in Alport syndrome and thin basement membrane nephropathy | Research Promotion Foundation Cyprus (EXCELLENCE/1216/0417) Funding: 250.000,00 € | Researcher |
| January 2017 | Donkey Milk Bioactive Powder | Research Promotion Foundation Cyprus (ENTERPRISES/0916/0083) Funding: 200.000,00 € | Researcher |
| November 2014 | RNA sequencing of diffuse large B-cell lymphoma | Karolinska Institutet’s 2014 Research Foundation Grant. Grant Number: H553104033 (2014fobi41242) Funding: 33,700.00 SEK | Scientific/Project Coordinator |
| October 2014 | Discovery of therapeutic targets in diffuse large B cell lymphoma | Wenner-Gren Foundation Funding: 20,000.00 SEK | Researcher |
| January 2012 | Creation of a kidney specific Biobank and infrastructure for genomics/proteomics research | European Regional Development Fund and the Republic of Cyprus through the Research Promotion Foundation (Strategic Infrastructure Project NEW INFRASTRUCTURE/STRATEGIC/0308/24) Funding: 2.0 million € | Researcher |
| January 2010 | Hellenic Obstetrics and Gynecology Society | Detection of trophoblastic cells at the outer cervical hilum of pregnant women using an automated FISH system. Contribution to the establishment of non-invasive prenatal diagnosis during the first semester of pregnancy Funding: 22,000 € | Researcher |
Academic Consulting Services/Councils/Boards/Editorial Committees
| Period | Organization | Title of Position or Service | Key Activities |
| January 2021-today | BMC Cancer | Member of the Editorial board | Editorial handling of submitted manuscripts |
| January 2020-today | Applied Sciences (MDPI) | Editor in the Special Issue "Big Data Analytics for Cancer Research and Precision Medicine” | Editorial handling of submitted manuscripts |
| May 2020-today | Critical Reviews in Oncogenesis (CRO) | Member of the Editorial board | Editorial handling of submitted manuscripts |
| October 2019-today | Cancer Molecular Targets and Therapeutics | Member of the Editorial board (Guest Associate Editor) | Editorial handling of submitted manuscripts |
| July 2017-today | Journal of Biotechnology Science Research | Member of the Editorial board | Editorial handling of submitted manuscripts |
Awards/International Recognition
| Date | Title | Awarded by: |
| 17 November 2018 | 2nd best presentation award | 6th International Multithematic Bio-Medical Congress (IMBMC), School of Medicine, European University Cyprus |
| 29 October 2017 | 1st Young Investigator Award | The 3rd Cyprus Oncology Conference: New Frontiers in Cancer Prevention and Personalized Treatment. Limassol, Cyprus |
| 15 February 2017 | Science Award 2017 | Youth Board of Cyprus & Cooperative Central Bank Ltd. Limassol, Cyprus |
| 12-15 October 2014 | FEBS YTF bursary | FEBS Advanced course/workshop: FEBS Workshop on Decoding non-coding RNAs in development and cancer. Capri, Italy |
| 17-22 February 2014 | ESPCA-FAPESP Scholarship (Escola São Paulo de Ciência Avançada – Fundação de Amparo a Pesquisa do Estado de Sao Paulo) | ESPCA in Oncogenesis and Translational Medicine for the Treatment of Cancer. Ribeirão Preto, Brazil |
| 3-11 July 2013 | YSF/FEBS bursary | 13th Young Scientists Forum and 38th FEBS Congress. St. Petersburg, Russia. |
| 18-21 May 2013 | Best abstract in the Young Investigators category | 50th ERA EDTA Congress. Istanbul, Turkey |
| 4-9 September 2012 | FEBS bursary | 22nd IUBMB & 37th FEBS Congress. From Single Molecules to Systems Biology. Sevilla, Spain |
| 15 January 2010 | Procter & Gamble Award of Original Research “G. Papanikolaou” | Hellenic Obstetrics and Gynecology Society. |
| 20 October 2009 | Best presentation award | 3rd Inter-universitary Hospital Congress of Obstetrics and Gynecology. Heraklion, Crete, Greece |
Other Achievements
| Date | Title | Key Activities: |
| 1 December 2020 | Selected in the list of the top 2% of the world’s most-cited and influential in their main subfield discipline, on a new global list compiled by Stanford University team, which combined several metrics and published in the PLOS Biology journal | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000384 https://data.mendeley.com/datasets/btchxktzyw/2 |
| 2008-2018 | Reviewer | Ad hoc manuscript reviews for peer reviewed journals (publons.com/a/1365437/) |
| 20 May 2018 | Ad hoc evaluations | Member of the Examination Committee of Mr. Theodoulakis’ Christofi PhD thesis defence (University of Cyprus) |
| 3 May 2018 | Seminar provider | Invited research seminar in the Life Science Seminar Series, titled “Immune cytolytic activity in colorectal cancer”. School of Science and Technology, Örebro University, Sweden |
| 24 March 2018 | Invited lecturer | Invited lecture “Immune cytolytic activity in colorectal cancer”. 14th Conference of the Organization of Greek teachers of secondary education in Cyprus (ΟΕΛΜΕΚ). University of Nicosia, Cyprus. |
| September 2016-2017 | Proposal evaluator | Evaluator of proposals submitted to the Ministry of Energy, Trade, Industry and Tourism, Cyprus (YEEBT). |
| July 2016-July 2017 | EUC Faculty Development | Accomplishment of the EUC Faculty Development Program |
| 30 April 2017 | Café Scientifique speaker | The Warburg effect in cancer (Café Scientifique). Mediterranean Science Festival 2017. 27-30 April, Limassol, Cyprus |
| September 2016-today | Member of the EUC School of Sciences Council | Meetings attendance and decision voting |
| September 2016-today | Member of the EUC Research Council | Meetings attendance and decision voting |