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Apostolos Zaravinos
Associate Professor, Biological Sciences
The School of Sciences
Department of Life Sciences
Academic Qualifications
Qualification Year Awarding Institution Department Thesis title (Optional Entry)
Specialization in Genomic Data Science 2017-2018 Johns Hopkins University, Baltimore, Maryland, USA McKusick-Nathans Institute of Genetic Medicine Differential expression between fetal and aged brains
Specialization in Systems Biology 2014-2015 Systems Biology Center, New York, USA Icahn School of Medicine, Mount Sinai Identification of deregulated genes after single gene perturbation in mammalian cell lines or tissues
PhD in Medicine (par excellence) 2005-2008 University of Crete, Greece School of Medicine Mutations and differential expression of the oncogenes RAS and BRAF and detection of viral DNA in human nasal polyposis
BSc in Biology 2000-2005 University of Crete, Greece Department of Biology The role of Fras1/Frem proteins in basement membrane function
Employment History
Period of employment Employer Location Position
From To
June 2019 today European University Cyprus Department of Life Sciences, School of Sciences, Nicosia, Cyprus Associate Professor
October 2015 May 2019 European University Cyprus Department of Life Sciences, School of Sciences, Nicosia, Cyprus Assistant Professor
February 2014 February 2016 Karolinska Institutet Department of Laboratory Medicine, Laboratory of Immunogenetics, Stockholm, Sweden Senior Post-Doctoral Research Fellow
Year Title Other authors Journal and Publisher / Conference Vol. Pages
2021 Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis Roufas C, Georgakopoulos-Soares I, Zaravinos A NAR Cancer 3(1) zcab005
2020 Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer Mastrogamvraki N, Zaravinos A NPJ Syst Biol Appl 6(1) 23
2020 High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer Kitsou M, Ayiomamitis GD, Zaravinos A Int J Oncol 57(1) 237-248
2020 Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers Panayiotou T, Michael S, Zaravinos A, et al. PLoS pathogens 16(4) e1008468
2020 EMT factors and metabolic pathways in cancer Georgakopoulos-Soares I, Chartoumpekis DV, Kyriazopoulou V, Zaravinos A Front Oncol 10 499
2020 Current perspectives in cancer immunotherapy Christofi T, Baritaki S, Falzone L, et al Cancers 11(10) 1472
2019 Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer Zaravinos A, Roufas C, Nagara M, et al. J Exp Clin Cancer Res 38(1) 364
2016 Extraction and Analysis of Mammalian Gene Expression Signatures from GEO by the Crowd. Wang Z, Monteiro CD, Jagodnik KM, et al. Nat Commun 7 12846
2015 Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells. Björkman A, Qvist P, Du L, et al. Proc Natl Acad Sci U S A 112(7) 2157-62.
2014 Exome sequencing reveals novel mutation targets in diffuse large B cell lymphomas derived from Chinese patients. de Miranda NFCC, Georgiou K, Chen L, et al. Blood 124(16) 2544-53
Date Topic International / Local Location* Role in Exhibition
4-5 December 2020 Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis 8th International Cyprus Society of Human Genetics (CSHG) Virtual conference Nicosia, Cyprus Invited oral presentation
9-14 November 2020 Distinct genomic features across cytolytic subgroups in skin melanoma Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting during SITC 2020 Virtual Poster presentation
8-11 October 2020 Systems Approaches in the Common Metabolomics in Acute Lymphoblastic Leukemia and Rhabdomyosarcoma Cells: A Computational Approach GeNeDis 2020: Genetics, Geriatrics and Neurodegenerative diseases 2020 FORTH Foundation The Foundation for Research and Technology - Hellas (FORTH), Heraklion, Crete, Greece Oral presentation
4-6 November 2019 Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer EMBL Cancer Genomics 2019 Heidelberg, Germany Oral presentation
10-12 October 2019 Correlation of the expression of immune checkpoint molecules with the tumor-infiltrating lymphocyte load, and survival in colorectal cancer patients 24th World Congress on Advances in Oncology & 24th International Symposium on Molecular Medicine Mystras, Sparta, Greece Oral presentation
7-12 July 2018 Prognostic impact of immune cytolytic activity and its association with checkpoint molecules and TIL/TAN load in human malignancies The FEBS Congress 2018 - Prague, Czech Republic (International) Prague, Czech Republic Poster presentation
17-20 March 2018 Nrf2 Prevents Notch-induced Insulin Resistance And Tumorigenesis In Mice ENDO2018 (International) Chicago, Illinois, USA Oral presentation
5-8 November 2017 Immune cytolytic activity in colorectal cancer Cancer Genomics (International) EMBL Heidelberg, Germany Poster presentation
February 8-13, 2015 A novel IGH-PDL1 translocation is associated with PDL1 overexpression in a diffuse large B cell lymphoma Tumor Immunology: Multidisciplinary Science Driving Combination Therapy (International) Fairmont Banff Springs, Banff, Alberta, Canada Poster presentation
17-20 June, 2015 Exome and whole genome sequencing reveals novel genetic alterations in diffuse large B-cell lymphomas derived from Chinese patients 13th International Conference on Malignant Lymphoma (International) Lugano, Switzerland Oral presentation
Research Projects
Date Title Funded by Project Role*
June 2018 Functional and therapeutic implications of histone N-terminal acetyltransferase Naa40 in colorectal oncogenesis Research Promotion Foundation Cyprus (EXCELLENCE/1216/0036) Funding: 250.000,00 € Researcher
June 2018 Genetic modifiers in Alport syndrome and thin basement membrane nephropathy Research Promotion Foundation Cyprus (EXCELLENCE/1216/0417) Funding: 250.000,00 € Researcher
January 2017 Donkey Milk Bioactive Powder Research Promotion Foundation Cyprus (ENTERPRISES/0916/0083) Funding: 200.000,00 € Researcher
November 2014 RNA sequencing of diffuse large B-cell lymphoma Karolinska Institutet’s 2014 Research Foundation Grant. Grant Number: H553104033 (2014fobi41242) Funding: 33,700.00 SEK Scientific/Project Coordinator
October 2014 Discovery of therapeutic targets in diffuse large B cell lymphoma Wenner-Gren Foundation Funding: 20,000.00 SEK Researcher
January 2012 Creation of a kidney specific Biobank and infrastructure for genomics/proteomics research European Regional Development Fund and the Republic of Cyprus through the Research Promotion Foundation (Strategic Infrastructure Project NEW INFRASTRUCTURE/STRATEGIC/0308/24) Funding: 2.0 million € Researcher
January 2010 Hellenic Obstetrics and Gynecology Society Detection of trophoblastic cells at the outer cervical hilum of pregnant women using an automated FISH system. Contribution to the establishment of non-invasive prenatal diagnosis during the first semester of pregnancy Funding: 22,000 € Researcher
Academic Consulting Services/Councils/Boards/Editorial Committees
Period Organization Title of Position or Service Key Activities
January 2021-today BMC Cancer Member of the Editorial board Editorial handling of submitted manuscripts
January 2020-today Applied Sciences (MDPI) Editor in the Special Issue "Big Data Analytics for Cancer Research and Precision Medicine” Editorial handling of submitted manuscripts
May 2020-today Critical Reviews in Oncogenesis (CRO) Member of the Editorial board Editorial handling of submitted manuscripts
October 2019-today Cancer Molecular Targets and Therapeutics Member of the Editorial board (Guest Associate Editor) Editorial handling of submitted manuscripts
July 2017-today Journal of Biotechnology Science Research Member of the Editorial board Editorial handling of submitted manuscripts
Awards/International Recognition
Date Title Awarded by:
17 November 2018 2nd best presentation award 6th International Multithematic Bio-Medical Congress (IMBMC), School of Medicine, European University Cyprus
29 October 2017 1st Young Investigator Award The 3rd Cyprus Oncology Conference: New Frontiers in Cancer Prevention and Personalized Treatment. Limassol, Cyprus
15 February 2017 Science Award 2017 Youth Board of Cyprus & Cooperative Central Bank Ltd. Limassol, Cyprus
12-15 October 2014 FEBS YTF bursary FEBS Advanced course/workshop: FEBS Workshop on Decoding non-coding RNAs in development and cancer. Capri, Italy
17-22 February 2014 ESPCA-FAPESP Scholarship (Escola São Paulo de Ciência Avançada – Fundação de Amparo a Pesquisa do Estado de Sao Paulo) ESPCA in Oncogenesis and Translational Medicine for the Treatment of Cancer. Ribeirão Preto, Brazil
3-11 July 2013 YSF/FEBS bursary 13th Young Scientists Forum and 38th FEBS Congress. St. Petersburg, Russia.
18-21 May 2013 Best abstract in the Young Investigators category 50th ERA EDTA Congress. Istanbul, Turkey
4-9 September 2012 FEBS bursary 22nd IUBMB & 37th FEBS Congress. From Single Molecules to Systems Biology. Sevilla, Spain
15 January 2010 Procter & Gamble Award of Original Research “G. Papanikolaou” Hellenic Obstetrics and Gynecology Society.
20 October 2009 Best presentation award 3rd Inter-universitary Hospital Congress of Obstetrics and Gynecology. Heraklion, Crete, Greece
Other Achievements
Date Title Key Activities:
1 December 2020 Selected in the list of the top 2% of the world’s most-cited and influential in their main subfield discipline, on a new global list compiled by Stanford University team, which combined several metrics and published in the PLOS Biology journal  
2008-2018 Reviewer Ad hoc manuscript reviews for peer reviewed journals (
20 May 2018 Ad hoc evaluations Member of the Examination Committee of Mr. Theodoulakis’ Christofi PhD thesis defence (University of Cyprus)
3 May 2018 Seminar provider Invited research seminar in the Life Science Seminar Series, titled “Immune cytolytic activity in colorectal cancer”. School of Science and Technology, Örebro University, Sweden
24 March 2018 Invited lecturer Invited lecture “Immune cytolytic activity in colorectal cancer”. 14th Conference of the Organization of Greek teachers of secondary education in Cyprus (ΟΕΛΜΕΚ). University of Nicosia, Cyprus.
September 2016-2017 Proposal evaluator Evaluator of proposals submitted to the Ministry of Energy, Trade, Industry and Tourism, Cyprus (YEEBT).
July 2016-July 2017 EUC Faculty Development Accomplishment of the EUC Faculty Development Program
30 April 2017 Café Scientifique speaker The Warburg effect in cancer (Café Scientifique). Mediterranean Science Festival 2017. 27-30 April, Limassol, Cyprus
September 2016-today Member of the EUC School of Sciences Council Meetings attendance and decision voting
September 2016-today Member of the EUC Research Council Meetings attendance and decision voting