Athanasios Metaxas
Assistant Professor, Pharmacy
22559661
School of Sciences
Department of Life Sciences
Academic Qualifications
| Qualification | Year | Awarding Institution | Department |
| Ph.D. | 2010 | University of Surrey, U.K. | School of Biosciences and Medicine |
| M.Sc. | 2005 | University of Surrey, U.K. | School of Biosciences and Medicine |
| B.Sc. | 2004 | Aristotle University of Thessaloniki, Greece | School of Pharmacy |
Employment History
| Period of employment | Employer | Location | Position | |
| From | To | |||
| 09/2020 | Current | European University Cyprus | Nicosia, Cyprus | Assistant Professor |
| 01/2015 | 12/2021 | University of Southern Denmark (SDU) | Odense, Denmark | Postdoc, Senior Postdoc, Visiting Researcher |
| 02/2010 | 06/2014 | Vrije Universiteit medisch centrum (VUmc) | Amsterdam, the Netherlands | Postdoc, Guest Researcher |
Publications
| Year | Title | Other authors | Journal and Publisher / Conference | Vol. | Pages |
| 2021 | Tumor necrosis factor (TNF) is required for spatial learning and memory in male mice under physiological, but not immune-challenged conditions | Leda Abbasowa Mygind, Marianne Skov-Skov Bergh, Vivien Tejsi, Ramanan Vaitheeswaran, Kate Lykke Lambertsen, Bente Finsen, Athanasios Metaxas | Cells | 10(3), 608 | doi: 10.3390/cells10030608 |
| 2019 | Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Post-Mortem Frontal Cortex of Alzheimer's Disease Patients. | Thygesen C, Briting SRR, Landau AM, Darvesh S, Finsen B. | Frontiers in Cellular Neuroscience | 13:538 | doi: 10.3389/fncel.2019.00538 |
| 2019 | Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. | Thygesen C, Kempf SJ, Anzalone M, Vaitheeswaran R, Petersen S, Landau AM, Audrain H, Teeling JL, Darvesh S, Brooks DJ, Larsen MR, Finsen B. | Scientific Reports | 9(1):15758 | doi: 10.1038/s41598-019-52357-5 |
| 2019 | Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. | Anzalone M, Vaitheeswaran R, Petersen S, Landau AM, Finsen B. | Alzheimer’s Research & Therapy | 11(1):38 | doi: 10.1186/s13195-019-0491-2 |
| 2018 | Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12-Month-Old APPswe/PSEN1dE9 Mice. | Vaitheeswaran R, Jensen KT, Thygesen C, Ilkjaer L, Darvesh S, Finsen B. | Current Alzheimer Research | 15(5):420-428 | doi: 10.2174/1567205014666171004113537 |
| 2018 | Age-Dependent Changes in the Sarkosyl-Insoluble Proteome of APPswe/PS1de9 Transgenic Mice Implicate Dysfunctional Mitochondria in the Pathogenesis of Alzheimer's Disease | Thygesen C, Larsen MR, Finsen B. | Journal of Alzheimer’s Disease: JAD | 64(4):1247-1259 | doi: 10.3233/JAD-180197 |
| 2016 | Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics. | Kempf SJ. | Neural Regeneration Research | 11(10):1579-1581 | doi: 10.4103/1673-5374.193234 |
| 2015 | Preclinical evaluation of [18F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors. | Golla SS, Klein PJ, Bakker J, Schuit RC, Christiaans JA, van Geest L, Kooijman EJ, Oropeza-Seguias GM, Langermans JA, Leysen JE, Boellaard R, Windhorst AD, van Berckel BN. | Nuclear Medicine and Biology | 42(2):205-12 | doi: 10.1016/j.nucmedbio.2014.09.006 |
| 2013 | Genetic deletion of the adenosine A(2A) receptor prevents nicotine-induced upregulation of α7, but not α4β2* nicotinic acetylcholine receptor binding in the brain. | Al-Hasani R, Farshim P, Tubby K, Berwick A, Ledent C, Hourani S, Kitchen I, Bailey A. | Neuropharmacology | 71:228-36 | doi: 10.1016/j.neuropharm.2013.03.023 |
| 2012 | The stereotypy-inducing and OCD-like effects of chronic 'binge' cocaine are modulated by distinct subtypes of nicotinic acetylcholine receptors. | Keyworth H, Yoo J, Chen Y, Kitchen I, Bailey A. | British Journal of Pharmacology | 167(2):450-64 | doi: 10.1111/j.1476-5381.2012.02023.x |
Exhibitions
| Date | Topic | International / Local | Location* | Role in Exhibition |
| 11/2018 | Tauopathy in the APPswe/PS1dE9 mouse model of familial AD | International | The Lundbeckfonden Brain Prize Meeting: Middelfart, Denmark | Oral Presentation |
| 11/2017 | Modelling progressive cognitive impairment in the APPswe/PS1dE9 mouse model of amyloidosis by using the Barnes maze test | International | 47th Society for Neuroscience (SfN) Meeting: Washington, DC, USA | Oral Presentation |
| 7/2016 | Examination of Alzheimer’s-related positive, negative and reactive pathology in the brainstem of APPswe/PS1ΔE9 mice | International | 10th FENS Forum of Neuroscience: Copenhagen, Denmark | Poster Presentation |
| 5/2014 | PET imaging of the NMDA receptor in the rhesus macaque brain with [18F]PK-209 | International | 10th International Symposium on Functional NeuroReceptor Mapping of the Living Brain: Egmond aan Zee, the Netherlands | Oral Presentation |
| 01/2014 | Applications of Autoradiography | International | Dutch Society for Clinical Radiochemistry: Groningen, the Netherlands | Invited Talk |
| 7/2012 | Over activation of NMDA receptors in the aged APPswe.PS1dE9 brain, a mouse model of Alzheimer’s disease | International | Alzheimer’s Association International Conference (AAIC): Vancouver, Canada | Poster Presentation |
| 10/2009 | Neuronal nicotinic receptor subtypes differentially influence cocaine-induced locomotor activity and stereotypy following a chronic ‘binge’ treatment | International | 39th Society for Neuroscience (SfN) Meeting: Chicago, IL, USA | Poster Presentation |
Research Projects
| Date | Title | Funded by | Project Role* |
| 2018-2020 | Functional Significance of Serotonergic Signalling in Innate Microglial Cells in the Normal and Alzheimer's Diseased Brain | Independent Research Fund Denmark (DFF) | Co-Investigator |
| 2016 | Neurofibrillary tangles in the APPswe/PS1ΔE9 model of familial Alzheimer’s disease | A.P. Møller and Chastine Mc-Kinney Møller Fonden til Lægevidenskabens Fremme (16-241) | Principal Investigator |
| 2015 | Are pro-inflammatory cytokines involved in regulating the anti-amyloid efficacy of Selective Serotonin Reuptake Inhibitors (SSRIs)? | A.P. Møller and Chastine Mc-Kinney Møller Fonden til Lægevidenskabens Fremme (15-267) | Principal Investigator |
| 2015-2018 | CoPING AD: COllaborative Project on the Interaction between Neurons and Glia in Alzheimer’s Disease | University of Southern Denmark (SDU2020) | Researcher |
| 2010-2014 | LeARN: Development and evaluation of tools for an earlier and more reliable diagnosis of Alzheimer’s Disease | Center for Translational Molecular Medicine (CTMM; 02N-101) | Researcher |
| 2006-2010 | GENADDICT: Genomics, mechanisms and treatment of addiction | European Commission (FP7; LSHM-CT2004-005166) | Researcher |
Academic Consulting Services/Councils/Boards/Editorial Committees
| Period | Organization | Title of Position or Service | Key Activities |
| 2016-2017 | Innovation Fund Denmark | Grant proposal reviewer | Assessing grant proposals |
| 2016-2017 | University of Southern Denmark (SDU) | Erasmus+ Coordinator | Planned schedule for traineeships, developed knowledge, skills and competence objectives, monitoring and evaluation plans |
| 2012-2013 | Vrije Universiteit medisch centrum (VUmc) | Coordinator; Professional Training Year | Coordinated the placement department, ensured compliance with placement regulations, wrote placement reports |
| 2008-2009 | University of Surrey | Curriculum Contribution | Co-developed the learning objectives and assessment criteria for a session of Practical Toxicology in M.Sc. course TOXM0007 |
| 2008-ongoing | SDU, VUmc, University of Surrey | Supervisor | Design and supervision of undergraduate & postgraduate thesis |
Awards/International Recognition
| Date | Title | Awarded by: |
| 2018 | IMM Travel Award | University of Southern Denmark |
| 2017 | Lundbeckfonden Travel Award | The Lundbeck Foundation |
| 2016 | IMM Travel Award | University of Southern Denmark |
| 2006-2010 | Ph.D. Studentship | European Commission |