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Charalambos Michaeloudes

Assistant Professor, Medical Research

[email protected]

22559510

School of Medicine

Department of Medicine

Academic Qualifications

Qualification Year Awarding Institution Department
PhD in Clinical Medicine Research 2009 Imperial College London Medicine
MSc in Molecular Life Sciences Research (Distinction) 2005 King’s College London Health and Life Sciences
BSc in Medical Biochemistry 2003 King’s College London Health and Life Sciences

Employment History

Period of employment Employer Location Position
From To
2019 Present Imperial College London London, UK Honorary Research Fellow
2019 2021 University of Cyprus/European Respiratory Society Nicosia, Cyprus European Respiratory Society Long-Term Fellow
2009 2019 Imperial College London London, UK Research Associate

Publications

Year Title Other authors Journal and Publisher / Conference Vol. Pages
2022 Mitochondrial transfer regulates cellular bioenergetics in healthy and COPD airway smooth muscle cells. Julia Frankenberg Garcia, Xie Li, Andrew V Rogers, Judith CW Mak, Andrew J Halayko, Christopher KM Hui, Mary Ip, Kian Fan Chung, Tristan Rodriguez, Charalambos Michaeloudes, Pankaj K. Bhavsar Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2022-0041OC
2022 Molecular mechanisms of oxidative stress in asthma. Charalambos Michaeloudes, Hisham Abubakar-Waziri, Ramzi Lakhdar, Katie Raby, Piers Dixey, Ian M Adcock, Sharon Mumby, Pankaj K. Bhavsar and Kian Fan Chung. Mol Aspects Med. 85: 101026
2022 ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells Chen R, Michaeloudes C, Liang Y, Bhavsar PK, Chung KF, Ip MSM, Mak JCW. J Allergy Clin Immunol. 149(4) 1445-1457
2021 Study of Mesenchymal Stem Cell-Mediated Mitochondrial Transfer in In Vitro Models of Oxidant-Mediated Airway Epithelial and Smooth Muscle Cell Injury Michaeloudes C, Li X, Mak JCW, Bhavsar PK. Methods Mol Biol. 2269 93-105
2020 Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases Michaeloudes C, Bhavsar PK, Mumby S, Xu B, Hui CKM, Chung KF, Adcock IM.   J Innate Immun. 12(1) 31-46
2018 Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways Michaeloudes C*, Li X*, Zhang Y, Wiegman CH, Adcock IM, Lian Q, Mak JCW, Bhavsar PK, Chung KF * Equal contribution J Allergy Clin Immunol. 141(5) 1634-1645
2017 Metabolic re-patterning in COPD airway smooth muscle cells. Michaeloudes C, Kuo CH, Haji G, Finch DK, Halayko AJ, Kirkham P, Chung KF, Adcock IM; COPDMAP   Eur Respir J. 50(5):1700202.
2015 Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease Michaeloudes C*, Wiegman CH*, Haji G*, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM; COPDMAP. * Equal contribution J Allergy Clin Immunol. 136(3) 769-780
2014 Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression Michaeloudes C*, Mercado N*, Clarke C, Bhavsar PK, Adcock IM, Barnes PJ, Chung KF. * Equal contribution   J Immunol. 192(10) 4913-4920
2011 Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma Michaeloudes C, Chang PJ, Petrou M, Chung KF.   Am J Respir Crit Care Med. 184(8) 894-903

Exhibitions

Research Projects

Date Title Funded by Project Role*
2020 - 2024 Role of mitochondria and cellular metabolism in severe eosinophilic asthma National Heart and Lung Institute PhD studentship PhD co-supervisor
2019 - 2021 Mitochondrial movement in airway smooth muscle cells in response to oxidative stress and inflammation European Respiratory Society Long-Term Research Fellowship Principal Investigator
2017 - 2022 Mechanisms that regulate mitochondrial transfer in health and disease Imperial College Centre for Translational and Experimental Medicine/British Heart Foundation Co-Investigator/ PhD co-supervisor
2017 - 2022 Tripartite Experts Programme at The University of Hong Kong-Shenzhen Hospital: The University of Hong Kong-Shenzhen Hospital, in collaboration with NHLI Sanming Project of Medicine – Shenzhen local government, China Scientific Advisor
2015 – 2017 Modulation of redox-based airway remodelling in COPD through lysine acetylation and BET bromodomains Dunhill Trust Research Grant Researcher
2013 – 2015 Mechanisms driving airway remodelling in COPD COPD MRC/ABPI Partnership (COPD MAP) - Work package 3 Researcher
2009 – 2013 Investigation of mechanisms driving oxidant-antioxidant imbalance in asthma Wellcome Trust Project Grant Researcher

Academic Consulting Services/Councils/Boards/Editorial Committees

Period Organization Title of Position or Service Key Activities
2021 - Present Biomolecules - MDPI Member of Topical Advisory Panel on Cell Biochemistry -       Reviewing manuscripts -       Designing and setting up special issues -       Advising the Editorial Board on manuscripts in area of expertise
2020 - Present European Respiratory Society Member of the European Respiratory Society College of Experts -       Assessing fellowship proposals -       Assessing career award nominations
2018 - Present European Respiratory Society Abstract reviewer – European Respiratory Society International Congress -       Reviewing abstracts on airway cell biology and immunopathology

Awards/International Recognition

Date Title Awarded by:
2020 European Respiratory Society (ERS) Travel Bursary to attend the ERS Lung Science Conference European Respiratory Society
2015 European Respiratory Society (ERS) Young Scientist Sponsorship to attend the ERS Annual Congress European Respiratory Society
2012 British Lung Foundation (BLF) Travel Fellowship to attend the ERS Annual Congress British Lung Foundation
2010 Asthma UK Travel Award to attend the ERS Annual Congress Asthma UK
2010 European Respiratory Society (ERS) Young Scientist Sponsorship to attend the ERS Annual Congress European Respiratory Society
2005 National Heart and Lung Institute PhD studentship National Heart and Lung Institute, Imperial College London

Other Achievements