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Vasiliki Gkretsi
Associate Professor, Biomedical Sciences
22559630
The School of Sciences
Department of Life Sciences
Academic Qualifications
Qualification Year Awarding Institution Department Thesis title
Ph.D 2006 University of Pittsburgh Medical School, PA, USA Department of Cellular and Molecular Pathology Role of integrin-proximal complexes in cancer cell behavior and normal liver function.
Diploma in Biology 2001 National and Kapodistrian University of Athens, Greece Biology Department Familial Mediterranean Fever (FMF) and screening for mutations of the MEFV gene in Greeks and in the Greek population of Cyprus.
 
Employment History
Period of employment Employer Location Position
From To
2021 Present European University Cyprus Nicosia, Cyprus Associate Professor
2017 2020 European University Cyprus Nicosia, Cyprus Assistant Professor
2015 2017 University of Cyprus Nicosia, Cyprus Senior Scientist
2009 2015 Centre for Research and Technology, Hellas (CE.R.T.H), Institute of Research and Technology-Thessaly (IRETETH), Department of Biomedical Sciences Larissa, Greece Research Assistant Professor (Researcher C)
 
Publications
Year Title Other authors Journal and Publisher / Conference Vol. Pages
2020 The focal adhesion protein Integrin Linked Kinase (ILK) as an important player in breast cancer pathogenesis Tsirtsaki K., and Gkretsi V. Cell Adhesion and Migration 14(1) 204-213
2020 Ras Suppressor-1 (RSU-1) in cancer cell metastasis; a tale of a tumor suppressor Louca M., Stylianopoulos T., and Gkretsi V. International Journal of Molecular Sciences 21(11) 4076
2020 Growth Differentiation Factor-15 (GDF-15) in cancer cell metastasis: from the cells to the patients Spanopoulou A., and Gkretsi V*. Clinical & Experimental Metastasis 37(4) 451-464
2020 ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating  ROCK1 and Fascin-1 Louca M., Zaravinos A., Stylianopoulos T, and Gkretsi V Molecular and Cellular Biochemistry 471(1-2) 143-153
2020 Silencing of Growth Differentiation Factor-15 promotes breast cancer cell invasion by downregulating focal adhesion genes. Gkretsi V.*, Stylianou A., Kalli M., Louca M., Voutouri C., Zaravinos A., Stylianopoulos T* Anticancer Res 40 (3) 1375-1385
2019 Inhibition of Breast Cancer cell invasion by Ras Suppressor-1 (RSU-1) silencing is reversed by Growth Differentiation Factor-15 (GDF-15). Gkretsi V, Louca M, Stylianou A, Minadakis G, Spyrou GM, Stylianopoulos T. International Journal of Molecular Sciences 20 (1) Pii:E163
2019 Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform. Gkretsi V*., Kalli M., Efstathiades C., Papageorgis P., Papanikolaou V., Zacharia LC., Tsezou A., Athanassiou E., Stylianopoulos T.* Scientific Reports 9(1) 10050
2019 Ras suppressor-1 (RSU-1) promotes cell iinvasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation Louca M., Stylianou A., Minia A., Pliaka V., Alexopoulos LG., Gkretsi V.*, and Stylianopoulos T*. Scientific Reports 9(1) 7782
2015 Ras Suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples Giotopoulou N., Valiakou V., Papanikolaou V., Dubos S., Athanassiou E., Tsezou A., Zacharia LC, Gkretsi V.* Clinical & Experimental Metastasis 32(3) 255-65
2008 Liver specific ablation of Integrin-Linked Kinase in mice results in abnormal histology, enhanced cell proliferation and hepatomegaly Gkretsi V., Apte U., Mars WM., Bowen WC., Luo JH., Yang Y., Yu YP., Orr A., St.-Arnaud R., Dedhar S., Kaestner KH., Wu C., Michalopoulos GK. Hepatology 48 (6) 1932-1941
 
Exhibitions
Date Topic International / Local Location* Role in Exhibition
March 29-30th, 2019 Targeting metastasis. Could RSU-1 be the key? Local 1st SynBio Conference in Cyprus, Nicosia, Cyprus Oral presentation
December 7th 2018 Inhibition of breast cancer cell invasion by Ras suppressor-1 (RSU-1) silencing is reversed by Growth Differentiation Factor-15 (GDF-15) International International Conference of the Cyprus Society of Human Genetics, Nicosia Cyprus Oral presentation
November 15-17, 2018 Depletion of Ras Suppressor-1 promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform International 6th International Multithematic Bio-Medical Congress, Nicosia, Cyprus Oral presentation
June 25-28, 2017   Identification of Ras Suppressor-1 (RSU-1) and Vasodilator-Stimulated Phosphoprotein (VASP) as potential breast cancer metastasis biomarkers using a three-dimensional in vitro approach. International 7th International Conference on Tumor-Host Interaction and Angiogenesis, Ascona, Switzerland Poster presentation
October 6-8, 2016 Targeting breast cancer metastasis: a bioengineering approach International 21st World Congress on Advances in Oncology & 19th International Symposium of Molecular Medicine, Athens, Greece Oral presentation
November 9, 2008 Validation of therapeutic siRNA approaches in animal models of TNF mediated chronic inflammatory diseases. Therapy for rheumatoid arthritis (RA): Targeting the actin cytoskeleton? International RIGHT Symposium “RNAi for Therapy”, Lisbon, Portugal Oral presentation
April 1-5, 2006 Depletion of Integrin-linked kinase (ILK) from primary mouse hepatocytes leads to apoptosis International FASEB, Experimental Biology meeting, San Francisco, CA, USA Oral presentation
April 2-6, 2005 Physical and functional association of migfilin with cell-cell adhesions International Experimental Biology meeting, San Diego, CA, USA Oral presentation
Research Projects
Date Title Funded by Project Role*
2021-2024 Identification of Medicinal/Aromatic Plants properties and improving quality, nutritive value and storability of fresh and dry products to support SME competitiveness Research Promotion Foundation (Excellence hub) Participant
2013-2014 The role of integrin-proximal protein complexes during hepatocellular carcinoma metastasis (renewal) European Society for the Study of the Liver, 2012 EASL Sheila Sherlock award   Principal investigator (project coordinator)
2012-2013 The role of integrin-proximal protein complexes during hepatocellular carcinoma metastasis European Society for the Study of the Liver, 2012 EASL Sheila Sherlock award Principal investigator (project coordinator)
2012-2015 Smart pole of specialization and development-Thessaly; Research, innovation and strategics Ministry of Education, religious affairs, culture and sports / General Secretariat for Research and Technology (GSRT) Co-Principal investigator (co-coordinator)
2007-2013 Osteoarthritis: complete systematic analysis for targeted biologic therapy General Secretariat for Research and Technology (GSRT). Action: NSFR 2007-2013, Cooperation, Protocol number: 12-11/09 #705   Co-Principal investigator (co-coordinator)
 
Academic Consulting Services/Councils/Boards/Editorial Committees
Period Organization Title of Position or Service Key Activities
2020-2022 Journal “Life” with an impact factor of 3.817 Special Issue Editor. Title “Cancer cell metastasis: the in vitro approach” Evaluation and selection of articles to be published in the special issue of the journal.
2018-2021 Committee of Bioethics Evaluation of Biomedical and Clinical Research B Member Evaluation of research proposals submitted to the committee from the perspective of bioethics.
2018-present European University Cyprus Representative of the School of Sciences at the Internal Quality Assurance Committee of the European University Cyprus. Quality assurance for academic programs in the School of Sciences.
2019-2020 International Journal of Molecular Sciences with an impact factor of 5.923 Special Issue Editor. Title Tumor Microenvironment and Actin Cytoskeleton in Cancer Cell Metastasis Evaluation and selection of articles to be published in the special issue of the journal.
2016-2017 Frontiers in Oncology journal with an impact factor of 6.244 Topic Editor   Title of Research Topic  “Metastasis: from cell adhesion and beyond”.
 
Awards/International Recognition
Date Title Awarded by:
2012-2014 European Association for the Study of the Liver (EASL*) Sheila Sherlock fellowship 2012, International Liver Congress 2012, April 18-22, Barcelona, Spain. Title of the research project: “The role of integrin-proximal protein complexes during hepatocellular carcinoma metastasis”. *EASL is the leading association in Europe attracting the foremost experts in hepatology, exhibiting an impressive track record in promoting cutting edge research in liver disease, supporting wider education and promoting changes in European liver policy. http://www.easl.eu/_fellowship/list-of-awardees/2012 European Association for the Study of the Liver (EASL)
2012 Travel award to attend the International Liver Congress 2012, April 18-22, Barcelona, Spain. European Association for the Study of the Liver (EASL)
2006 invited as student honoree and received the yellow ribbon at the Honors Convocation 2006 of the University of Pittsburgh, Carnegie Library, February 24th 2006, Pittsburgh, PA, USA University of Pittsburgh, PA, USA
2005 received the 2005-2006 Stephen L. Phillips Scientific Achievement Award at the 10th Annual University of Pittsburgh Biomedical Graduate Student Research Symposium, October 2005, Pittsburgh, PA, USA. This award is given in recognition of an outstanding first author publication and contribution to graduate research. University of Pittsburgh, PA, USA
2004 2004: received the American Society for Investigative Pathology (ASIP) Trainee Travel Award for the Experimental Biology meeting 2005, San Diego, CA, USA. American Society for Investigative Pathology
 
Other Achievements
Date Title Key Activities:
2005-present ·         45 peer reviewed articles and 3 book chapters ·         1st author in 20, 2nd in 11 and corresponding in 22 ·         1166 citations (Scopus), h index 18 ·         1690 citations (Google Scholar), h index 22 ·         Reviewer in 29 scientific journals  
2005 Journal of Cell Science (IF=6,144) cover photo from the article: Gkretsi V., et al.(2005) Physical and functional association of migfilin with cell-cell adhesions, J Cell Sci 118 (4), 697-710. An image from this work was selected for the cover of the Journal of Cell Science.
2009 Draft US provisional patent application-Application No. 61175960, Date of application: May 06, 2009 Title: “METHODS FOR TREATING INFLAMMATION”. Inventors: Georgios Kollias, Vasiliki Gkretsi, Yiannis Vasilopoulos. Patent