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Constantine Stratakis
Adjunct Professor, Pediatrics, Translation Medicine
Academic Qualifications
Qualification Year Awarding Institution Department Thesis title (Optional Entry)
MD 1989 University of Athens (EKPA) Athens, Greece School of Medicine
Doctor of Medical Sciences (Didaktorikon) 1994 University of Athens (EKPA) Athens, Greece School of Medicine Measurement and circadian variation of the IGF growth factors and their binding proteins
PhD (hc) 2012 Université de Liège School of Medicine
PhD (hc) 2018 University of Athens (EKPA) Athens, Greece School of Medicine
Employment History
Period of employment Employer Location Position
From To
July 1st 1990 June 30th 1996 Georgetown University Washington, DC Intern, resident, fellow, paediatrics, endocrinology and genetics
July 1st 1993 February 28, 2021 National Institutes of Health (NIH) Bethesda, MD Senior Investigator
March 1st, 2021 today ELPEN, Inc. & FORTH ( Athens, Greece & Heraklion, Crete, Greece CSO, Director, Research Institute & Director of Research
Year Title Other authors Journal and Publisher / Conference Vol. Pages
2000 Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the carney complex Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS & CA Stratakis Nature Genetics 26 89-92
2006 A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia Horvath A, Boikos S, Giatzakis C, Robinson-White A, Groussin L, Griffin KJ, Stein E, Levine E, Delimpasi G, Hsiao H-P, Keil M, Heyerdahl S, Matyakhina L, Libe R, Fratticci A, Kirschner LS, Cramer K, Gaillard RC, Bertagna X, Carney JA, Bertherat J, Bossis I & CA Stratakis Nature Genetics 38 794-800
2007 Mutations of the genes coding for the succinate dehydrogenase subunit genes in familial gastrointestinal tumors McWhinney SR, Pasini B & CA Stratakis New England Journal of Medicine 357 1054-1056
2008 Mutation in PDE8B, a cAMP-specific phosphodiesterase in adrenal hyperplasia Horvath A, Mericq V & CA Stratakis New England Journal of Medicine 358 750-752
2008 Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone Tsang KM, Starost MF, Nesterova M, Boikos SA, Watkins T, Almeida MQ, Harran M, Li A, Collins MT, Cheadle C, Mertz EL, Leikin S, Kirschner LS, Robey P & CA Stratakis Proceedings of the National Academy of Sciences USA 107 8683-8688
2011 Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Janeway KA, Kim SY, Lodish M, Nosé V, Rustin P, Gaal J, Dahia PL, Liegl B, Ball ER, Raygada M, Lai AH, Kelly L, Hornick JL; NIH Pediatric and Wild-Type GIST Clinic, O'Sullivan M, de Krijger RR, Dinjens WN, Demetri GD, Antonescu CR, Fletcher JA, Helman L & CA Stratakis Proceedings of the National Academy of Sciences USA 108 314-318
2014 Constitutive activation of PRKACA in adrenal Cushing's syndrome Beuschlein F*, Fassnacht M*, Assié G*, Calebiro D*, Stratakis CA*, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz F, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabbin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B *first authors New England Journal of Medicine 370 1019-1028
2014 Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra Mde L, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A & CA Stratakis New England Journal of Medicine 371 2363-2374
2018 Activating PRKACB somatic mutation in cortisol-producing adenomas Espiard S, Knape MJ, Bathon K, Assié G, Rizk-Rabin M, Faillot S, Luscap-Rondof W, Abid D, Guignat L, Calebiro D, Herberg FW, Stratakis CA, Bertherat J. Journal of Clinical Investigation Insight 3 e98296
2020 Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation London E, Wester JC, Bloyd M, Bettencourt S, McBain CJ, Stratakis CA Journal of Clinical Investigation Insight 5(23) e141670
Research Projects
Ref. Number Date Title Funded by Project Role*
Z01 HD008920: 1995-2021 Molecular genetics of endocrine tumors and related disorders NIH Principal Investigator
Academic Consulting Services/Councils/Boards/Editorial Committees
Ref. Number Period Organization Title of Position or Service Key Activities
1 2017-2020 SPR Executive Council Running the Society for Pediatric Research
2 2019-2020 SPR President The head of the Society for Pediatric Research
3 2017-today Molecular & Cellular Endocrinology Co-Editor-in-Chief Leading along with 3 other co-editors one of the most respected journals in endocrinology
4 2015-today Hormone & Metabolic Research Co-Editor-in-Chief Editing along with 2 other co-editors one of the leading journals in clinical endocrinology
5 2021 Sync, Inc Chair, Scientific Advisory Board Leading the science of one of the most important Greek-owned companies in life sciences
Awards/International Recognition
Ref. Number Date Title Awarded by:
1 1999 Endocrine Society (USA)-Pharmacia Award for Excellence in Published Clinical Research (USA) Endocrine Society
2 2009 Ernst Oppenheimer Award (USA) Endocrine Society
3 2000, 2005, 2007 NIH MERIT AWARDS (USA) National Institutes of Health
4 2015 NICHD, NIH MENTOR OF THE YEAR (USA) National Institutes of Health
5 2016 Distinguished Physician 2016 Award Hellenic Medical Society of New York
6 2013 Honorary Doctorate (PhD) University of Liege, Belgium
7 2018 Honorary Doctorate (PhD) University of Athens, Greece
8 2018 International Award for Excellence in Pediatric Endocrinology European Society for Pediatric Endocrinology (ESPE)
9 2019 Honorary Member Hellenic Endocrine Society
10 2019 DALE Medal (UK) Society for Endocrinology
Other Achievements