Ioannis Trougakos
Adjunct Professor, Systems Biology of Ageing & Cancer
22713000
School of Sciences
Adjunct Faculty
Academic Qualifications
| Qualification | Year | Awarding Institution | Department | Thesis title |
| PhD | 1997 | National and Kapodistrian University of Athens | Faculty of Biology | The evolutionary relationships of various species of the genus Drosophila as revealed by electrophoretical analysis and electron microscopy |
| BSc | 1990 | National and Kapodistrian University of Athens | Faculty of Biology |
Employment History
| Period of employment | Employer | Location | Position | |
| From | To | |||
| 2009 | present | National and Kapodistrian University of Athens | Athens, Greece | Assistant / Associate Professor |
| 2005 | 2009 | National Hellenic Research Foundation | Athens, Greece | Research Lecturer |
| 2002 | 2005 | National Hellenic Research Foundation | Athens, Greece | Post-Doc |
Publications
| Year | Title | Other authors | Journal and Publisher / Conference | Vol. | Pages |
| 2018 | Molecular mechanisms of Carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of Metformin | Efentakis E, Kremastiotis G, Varela A, Nikolaou PE, Papanagnou ED, Davos CH, Tsoumani M, Agrogiannis G, Konstantinidou A, Kastritis E, Kanaki Z, Iliodromitis EK, Klinakis A, Dimopoulos MA, Trougakos IP, Andreadou I, Terpos E | Blood | In press | |
| 2018 | Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy | Tsakiri EN, Gumeni S, Vougas V, Pendin D, Papassideri I, Daga A, Gorgoulis V, Juhász G, Scorrano L, Trougakos IP | Autophagy | In press | |
| 2018 | Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation | Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP | Aging Cell | In press | |
| 2018 | Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights | Cheimonidi C, Samara P, Polychronopoulos P, Tsakiri EN, Nikou T, Myrianthopoulos V, Sakellaropoulos T, Zoumpourlis V, Mikros E, Papassideri I, Argyropoulou A, Halabalaki M, Alexopoulos LG, Skaltsounis AL, Tsitsilonis OE, Aligiannis NN, Trougakos IP | Redox Biol | 16 | 169-178 |
| 2018 | Cancer chemoprevention via activation of proteostatic modules | Sklirou A, Papanagnou ED, Fokialakis N, Trougakos IP | Cancer Lett | 413 | 110-121 |
| 2017 | The Indirubin Derivative 6-Bromoindirubin-3'-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects | Tsakiri EN, Gaboriaud-Kolar N, Iliaki KK, Tchoumtchoua J, Papanagnou ED, Chatzigeorgiou S, Tallas KD, Mikros E, Halabalaki M, Skaltsounis AL, Trougakos IP | Antioxid Redox Signal | 27 | 1027-1047 |
| 2013 | Natural compounds with anti-ageing activity | Argyropoulou A, Aligiannis N, Trougakos IP, Skaltsounis AL | Nat Prod Rep | 30 | 1412-037 |
| 2013 | Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging | Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP | Aging Cell | 12 | 802-13 |
| 2009 | Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex | Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS, Zou Y, Margaritis LH, Boothman DA, Gonos ES | Clin Cancer Res | 15 | 48-59 |
| 2004 | Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress | Trougakos IP, So A, Jansen B, Gleave ME, Gonos ES. | Cancer Res | 64 | 1834-42 |
Exhibitions
Research Projects
| Date | Title | Funded by | Project Role* |
| … - present | COST Actions (8) | EU | PI |
| 2017 | BioImaging-GR | GSRT, Greece | PI |
| 2017 | PlantUp-GR | GSRT, Greece | PI |
| 2015 | MediHealth (H2020 – RISE) | EU | PI |
| 2015 | TASCMAR (H2020 – Health) | EU | PI |
| 2014 | PABET | GSRT, Greece | PI |
| 2013 | SYNERGASIA II | GSRT, Greece | PI |
| 2013 | MICROSMETICS (FP7 – People) | EU | PI |
| 2012 | SYNERGASIA I | GSRT, Greece | PI |
| 2011 | INsPiRE (FP7 Capacities) | EU | PI (Deputy Coordinator) |
Academic Consulting Services/Councils/Boards/Editorial Committees
| Period | Organization | Title of Position or Service | Key Activities |
| 2018 | World Health Organization | Reviewer | World Cancer Report (2019) |
| 2018 | Swiss Cancer League | Reviewer | Grant Reviewer |
| 2018 | Austrian Science Fund | Reviewer | Grant Reviewer |
| 2016 | Dutch Cancer Society | Reviewer | Grant Reviewer |
| 2016 | COST Actions - EU | Reviewer | Grant Reviewer (Rapporteur) |
Awards/International Recognition
| Date | Title | Awarded by: |
| … - present | Invited Lectures in Hellenic, International Conferences, Universities, Research Institutes | Inviting Institute |
| … - present | Awards for Poster or Lecture Presentations in Hellenic or International Conferences | Organizing Committee |
| … - present | Research highlight, Cover page or Editorial of published Research Articles | Aging Cell (x2) , Clin Cancer Res, J Cell Biol, Aging, Cell Death Differ, Antioxid Redox Signal |
| … - present | Invited Editor in Special Issues | Redox Biol, Oxid Med Cell Longev, Marine Drugs |
| 2017 | Invitation for consultation on investment in innovative digital solutions for Active & Healthy Ageing | EU – ECHAlliance |
| 2014 | Invitation to be included in the Reviewers database of the EU H2020 programme | EU |
| 2012 | Invited participant in “European Innovation Partnership on Active and Healthy Ageing – from plan to Action” event at the EU parliament | EU |
| 2009-2010 | Invited participant in the EU workshops “Oxidative stress, protein damage and protein maintenance” and “Biomarkers of Aging and Longevity” of the project: WhyWeAge- A road map for molecular Biogerontology (HEALTH-F4-2008-200970) | Organizing Committee |
Other Achievements
| Date | Title | Key Activities: |
| 2018 | 91 articles in International Journals (86) or Books (5); 96 Hellenic Conference abstracts (lectures or posters); 135 International Conference abstracts (lectures or posters); 2 patents | Author / Researcher |
| 2018 | Citations: 10290*; h-index: 31*; i10-index: 61*; Total IF: 430; Mean article IF (for the 86 articles in international Journals): 4.99 ± 2.92 (as of November 30, 2018)* * Source: Google Scholar: https://scholar.google.gr/citations?user=pMAEpmkAAAAJ&hl=en&oi=ao | Author / Researcher |
| … - present | Reviewer in >85 International Scientific Journals, Organization of Hellenic and International Conferences | Reviewer / Organizer or Scientific Committee |
| … - present | Reviewer for “GSRT”, Greece; “National Science Centre”, Poland; “The Ministry of Education, Youth and Sports”, Czech Republic; “Nevi Netherlands”, the Netherlands; Israeli Ministry of Science, Technology and Space; Bulgarian National Science Fund; Research Promotion Foundation, Cyprus; Invited member of REPRISE (web-based database of expert reviewers created by the Italian MEUR) | Grant Reviewing |
| 2017 | Hellenic Scientific Society “Medical Society for the study of Cancer Biology and Therapy” | Founding member |
| 2014 | Invited evaluator for the Ministry of Education, Cyprus | Reviewer |
| 2012 | UoA Spin-off Company “Pharmagnose” | Founding member |
| 2010-present | Funding / Research contracts from Onyx Pharmaceuticals (USA), Korres (GR), Ethnodyne (FR), AMGEN (USA) | PI |
| 2010 | Research funding award from the “Empirikion” and “Bodosakis” Foundations | PI |
| 2000 | Fellowship from the Hellenic State Scholarships Foundation | Post-Doc |