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Christiana Neophytou
Assistant Professor
N/A
22713218
Academic Qualifications
Qualification Year Awarding Institution Department Thesis title (Optional Entry)
DPhil (PhD) in Molecular Biology 2014 University of Cyprus Biological Sciences Chemotherapeutic mechanism of action of d-alpha Tocopheryl Polyethylene Glycol Succinate (TPGS) in Breast Cancer
MSc in Experimental Molecular Biology 2010 University of Cyprus Biological Sciences Investigation of the apoptotic mechanism induced by natural isoforms and synthetic derivatives of Vitamin E in prostate cancer cell lines
BSc in Biology 2008 National and Kapodistrian University of Athens Biology Investigation of the mechanism of action of Benzopyrene in prostate cancer cell lines
Employment History
Period of employment Employer Location Position
From To
January 2019 August 2022 European University Research Center Nicosia, Cyprus Post Doctoral Researcher
January 2015 August 2019 University of Cyprus Nicosia, Cyprus Post Doctoral Researcher
2013 2014 University of Cyprus Nicosia, Cyprus Special Scientist
Publications
Year Title Other authors Journal and Publisher / Conference Vol. Pages
2022 Amygdalin acts as a chemoprotective agent in combination with the platinum drug Cisplatin Christodoulou P, Boutsikos P, Neophytou CM, Kyriakou TC, Christodoulou M, Papageorgis P, Stephanou A, Patrikios I Frontiers in Pharmacology 3996
2022 The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review Louro, H., B. C. Gomes, A. T. Saber, A. L. Iamiceli, T. Goen, K. Jones, A. Katsonouri, Neophytou C. M., U. Vogel, C. Ventura, A. Oberemm, R. C. Duca, M. F. Fernandez, N. Olea, T. Santonen, S. Viegas and M. J. Silva Toxics 10 8
2022 LC-HRMS/MS phytochemical profiling of Vernonia kotschyana Sch. Bip. ex Walp.: Potential involvement of highly-oxygenated stigmastane-type saponins in cancer cell viability, apoptosis and intracellular ROS production. Vasincu A, Luca SV, Charalambous C, Skalicka-Woźniak K, Miron A. South African Journal of Botany 144 83-91
2021 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance Trougakos I., Nuray E., and Papageorgis P. Cancers 13 17
2021 Anti-Cancer Activity and Phenolic Content of Extracts Derived from Cypriot Carob (Ceratonia siliqua L.) Pods Using Different Solvents Gregoriou G., Vasincu A., Gregoriou Y., Hatzipakkou H., Pinakoulaki E., Stavrou I., Christou A., Kapnisi C., Aigner S., Stuppner H., Kakas A., Constantinou A.I. Molecules 26 (16), 5017
2019 d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells Mesaritis A., Gregoriou G., Constantinou A.I Scientific Reports 9(1) 14375
2019 Mechanisms of Metastatic Tumor Dormancy and Implications for Cancer Therapy Kyriakou TC, Papageorgis P International journal of molecular sciences 20 24
2018 Molecular mechanisms and emerging therapeutic targets of triple-negative breast cancer metastasis Mpoutsikos P., and Papageorgis P Frontiers in         Oncology 8 31
2015 Targeting IL13Ra2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis Papageorgis P., Ozturk S., Lambert A.W., Tzatsos A., Wong C.K., Thiagalingam S. and Constantinou A.I., Breast Cancer Research 17(1) 98
2014 D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells Constantinou C., Papageorgis P., Constantinou A.I., Biochemical Pharmacology, 2014. 89 31-42
Exhibitions
Date Topic International / Local Location* Role in Exhibition
18-20 November 2021 Unveiling the transcriptional landscape that regulates colonization of dormant metastatic breast cancer cells to the lungs International 9th International Multithematic Scientific Bio-Medical Congress (IMBMC), Nicosia, Cyprus. Invited talk
5-9 September 2021 Unveiling the role of ATF4 in metastatic breast cancer dormancy International 4th Annual Conference of STRATAGEM “New Diagnostic and Therapeutic Tools against Multi-Drug Resistant Tumours”, Prague Invited talk
4-5th of December, 2020 Unveiling novel molecular mechanisms that regulate colonization of dormant metastatic breast cancer cells International 8th International Conference of The Cyprus Society of Human Genetics, online Invited talk
7-9 November 2019 Experimental Strategies to Unveil Novel Molecular Mechanisms that Regulate Colonization of Dormant Metastatic Breast Cancer Cells Local 7th International Multithematic Bio-Medical Congress (IMBMC), Nicosia, Cyprus. Poster Presentation
24-26 June 2019 Unveiling novel molecular mechanisms that regulate colonization of dormant metastatic breast cancer cells Local Advances in the Applications of Monoclonal Antibodies in Clinical Oncology, Grecian Park Hotel, Konnos Bay, Cyprus Invited talk
1 - 3 February 2018 d-α-tocopheryl polyethylene glycol 1000 succinate and a small molecule inhibitor of survivin synergistically induce apoptosis in breast cancer cells International EARC conference series, A Matter of Life or Death: From Basic Cell Death Mechanisms to Novel Cancer Treatments, Amsterdam, Netherlands Poster Presentation
28 November 2017 Development of a novel therapeutic approach for breast cancer based on the nano-formulation of a Small Molecule Inhibitor (SMI) of an anti-apoptotic protein Local 3rd INNOVATION & ENTREPRENEURSHIP FORUM, University of Cyprus Poster Presentation
November 3rd, 2017 Nanoparticle applications in cancer chemoprevention and therapy Local 5th International Bio-Medical Scientific Cyprus Congress, Nicosia Invited talk
March 13-16, 2013 Application of computational modeling for identifying promising agents to control breast cancer International 13th St. Gallen International Breast Cancer Conference, St Gallen, Switzerland. Poster Presentation
March 2012 D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces apoptosis and cell cycle arrest selectively in breast cancer cells by targeting aberrantly activated pathways engaging survivin signaling. International Proceedings of the American Assoc. Cancer Res. 53:1190, 2012. Poster Presentation
Research Projects
Date Title Funded by Project Role*
2022-2024 Targeting the desmoplastic tumor microenvironment to improve the efficacy of pancreatic cancer immunotherapy. The Research & Innovation Foundation Researcher
2021-2022 Examination of the chemopreventive and anti-cancer properties of plant extracts. Alpinamed Researcher
2019-2021 Unveiling novel molecular mechanisms that regulate colonization of dormant metastatic breast cancer cells The Research & Innovation Foundation Researcher
2017-2021 The European Human Biomonitoring Initiative The European Commission Researcher
2015-2019 Epigenetic Chemical Biology COST The European Commission Researcher
2011-2014 A Social Collaborative Working Space Semantically Interlinking Biomedical Researchers, Knowledge and Data for The Design and Execution of In-Silico Models and Experiments in Cancer Chemoprevention The European Commission Researcher
Academic Consulting Services/Councils/Boards/Editorial Committees
Period Organization Title of Position or Service Key Activities
2021-2024 Lobular Breast Cancer: Discovery Science, Translational Goals, Clinical Impact The European Commission Management Committee member
2019-2022 New diagnostic and therapeutic tools against multidrug resistant tumors The European Commission Management Committee member
Awards/International Recognition
Date Title Awarded by:
2021 Third Prize for the Best Oral Presentation for the talk “Unveiling the Role of ATF4 in Metastatic Breast Cancer Dormancy” 4th Annual Conference of STRATAGEM “New Diagnostic and Therapeutic Tools against Multi-Drug Resistant Tumours”
2019 Second place prize for the poster presentation “Experimental Strategies to Unveil Novel Molecular Mechanisms that Regulate Colonization of Dormant Metastatic Breast Cancer Cells” European University Cyprus at the 7th International Multithematic Bio-Medical Congress (IMBMC),
2017 Second place award for the abstract entitled synergistic effect of d-α-tocopheryl polyethylene glycol 1000 succinate and a small molecule inhibitor of survivin in breast cancer The 3rd Cyprus Oncology Conference
2016 1st Place award in the category of Post-Doctoral fellows The Molecular Medicine Research Center University of Cyprus as part of the Euro-BioCy Research Proposal Competition.
2015 New Researcher Grant for the submission of a research proposal to the Horizon2020 Call “H2020-PHC-2015-two-stage” under the topic PHC-14-2015. University of Cyprus
2013 New Researcher Grant for the submission of a research proposal to the MARIE CURIE ACTIONS-PEOPLE Call: FP7-PEOPLE-2013-IAPP Industry-Academia Partnerships and Pathways (IAPP). University of Cyprus
2010 1st Poster award for the poster presentation at the 10th Marianna Lordos Symposium Marianna Lordos Cancer Memorial Fund.
2010 Award for the highest GPA obtained in the MSc in Experimental Biology Graduating class of 2010 C.Georgiou (Lab Supplies) LTD.
Other Achievements